Hydrogen molecules (H2) improve perfusion recovery via antioxidant effects in experimental peripheral arterial disease
نویسندگان
چکیده
منابع مشابه
Skeletal Muscle Perfusion in Peripheral Arterial Disease
Peripheral arterial disease (PAD) is characterized by lower limb arterial obstruction due to atherosclerosis. There are over 8 million people with PAD in the U.S at present (1). As a consequence of impaired tissue perfusion, PAD patients can experience pain, diminished exercise capacity, and tissue loss, with some ultimately requiring amputation (2). The presence of PAD is a high risk marker of...
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Objective: Peripheral Arterial Disease (PAD) is a state characterized by atherosclerotic occlusive disease of lower extremities. Diabetes is the main risk factor for PAD. Material and Methods: To assess the prevalence of PAD, a cross sectional study was performed on 352 diabetic patients who referred to Yazd diabetes research center from 2007 to 2010. Vascular assessment was done by measuring ...
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In peripheral arterial disease (PAD) patients, occlusions in the major arteries that supply the leg makes blood flow dependent on the capacity of neovascularization. There is no current medication that is able to increase neovascularization to the ischemic limb and directly treat the primary problem of PAD. An increasing body of evidence supports the notion that inflammation plays an important ...
متن کاملEndothelial cells derived from human iPSCS increase capillary density and improve perfusion in a mouse model of peripheral arterial disease.
OBJECTIVE Stem cell therapy for angiogenesis and vascular regeneration has been investigated using adult or embryonic stem cells. In the present study, we investigated the potential of endothelial cells (ECs) derived from human induced pluripotent stem cells (hiPSCs) to promote the perfusion of ischemic tissue in a murine model of peripheral arterial disease. METHODS AND RESULTS Endothelial d...
متن کاملFast metastable hydrogen atoms from H2 molecules: twin atoms
It is a difficult task to obtain “twin atoms”, i.e. pairs of massive particles such that one can perform experiments in the same fashion that is routinely done with “twin photons”. One possible route to obtain such pairs is by dissociating homonuclear diatomic molecules. We address this possibility by investigating the production of metastable H(2s) atoms coming from the dissociation of cold H2...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2018
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2018.9546